Right Ventricular Pressure Overload and Pathophysiology of Growing Porcine Biomodel
| Autor: | Imran Saeed, Hideki Uemura, Anke Furck, K Pizingerova, Jiri Fremuth, Zdenek Slavik, Zbynek Tonar, Jiri Kobr |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Swine Heart Ventricles Ventricular Dysfunction Right Hemodynamics 030204 cardiovascular system & hematology Pulmonary artery banding 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Ventricular Pressure Enoximone Animals Pressure overload business.industry Myocardium medicine.disease Pulmonary hypertension 030104 developmental biology Blood pressure Pediatrics Perinatology and Child Health Ventricular pressure Cardiology Myocardial fibrosis Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Pediatric cardiology. 37(8) |
| ISSN: | 1432-1971 |
| Popis: | The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular haemodynamic parameters and myocardial changes in biomodel of right ventricular hypertension. The study included a total of 12 piglets of 42 days of age. Under general anaesthesia, pulmonary artery banding (PAB) was performed surgically to constrict the main pulmonary artery to about 70-80 % of its original dimension. The study presented two groups of animals labelled C (control animals with PAB; n = 8) and E (animals with PAB and oral administration of enoximone; n = 4). Direct pressure and echocardiographic measurements were taken during operation (time-1), and again at 40 days after surgery (time-2). The animals were killed, and tissue samples from the heart chambers were collected for quantitative morphological assessment. Statistical analysis was performed on all acquired data. At time-2, the median weight of animals doubled and the median systolic pressure gradient across the PAB increased (46.59 ± 15.87 mmHg vs. 20.29 ± 5.76 mmHg; p |
| Databáze: | OpenAIRE |
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