Nuclear positioning in migrating fibroblasts
Autor: | Chenshu Liu, Gregg G. Gundersen, Ruijun Zhu |
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Rok vydání: | 2018 |
Předmět: |
Cell Nucleus
0301 basic medicine Nesprin LINC complex Biological Transport Cell migration Cell Biology Fibroblasts Biology Article Fibroblast migration Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Cell Movement medicine Inner membrane Cytoskeleton Fibroblast Nucleus Developmental Biology |
Zdroj: | Seminars in Cell & Developmental Biology. 82:41-50 |
ISSN: | 1084-9521 |
Popis: | The positioning and movement of the nucleus has recently emerged as an important aspect of cell migration. Understanding of nuclear positioning and movement has reached an apogee in studies of fibroblast migration. Specific nuclear positioning and movements have been described in the polarization of fibroblast for cell migration and in active migration in 2D and 3D environments. Here, we review recent studies that have uncovered novel molecular mechanisms that contribute to these events in fibroblasts. Many of these involve a connection between the nucleus and the cytoskeleton through the LINC complex composed of outer nuclear membrane nesprins and inner nuclear membrane SUN proteins. We consider evidence that appropriate nuclear positioning contributes to efficient fibroblast polarization and migration and the possible mechanism through which the nucleus affects cell migration. |
Databáze: | OpenAIRE |
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