Reduced retention of cadmium in the liver of metallothionein-null mice
| Autor: | Masahiko Satoh, Yoshitaka Kanayama, Andy Choo, Chiharu Tohyama, Akira Naganuma, Naomi Kodama, A. E. Michalska, Hisao Nishimura |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Null mice Genetically modified mouse medicine.medical_specialty Cadmium Kidney Health Toxicology and Mutagenesis Liver and kidney Significant difference chemistry.chemical_element General Medicine Toxicology medicine.anatomical_structure Endocrinology chemistry Internal medicine Immunology medicine Metallothionein Distribution (pharmacology) |
| Zdroj: | Environmental Toxicology and Pharmacology. 1:213-216 |
| ISSN: | 1382-6689 |
| Popis: | The distribution of cadmium (Cd) in the organs of mice was studied using metallothionein (MT)-null transgenic mice. When mice were administered with Cd chloride at a single subcutaneous dose of 1.0 mg Cd/kg body weight, Cd accumulated mainly in the liver and kidney by 6 h after injection without any significant difference between the MT-null mice and control (C57BL/6J) mice. MT was not detected in these organs of MT-null mice both before and after Cd administration whereas MT was induced mainly in these organs of the control mice. There was a marked elimination of Cd from the liver of MT-null mice by 21 days after administration, compared with a relatively slow Cd elimination in the C57BL/6J mice. Under the condition that no significant liver or kidney damage was observed, MT was considered to play a significant role in the retention of Cd in the liver but not in the uptake of this metal. |
| Databáze: | OpenAIRE |
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