Dimethylated Thioarsenates: A Potentially Dangerous Blind Spot in Current Worldwide Regulatory Limits for Arsenic in Rice

Autor:	Britta Planer-Friedrich, Carolin F. Kerl, Andrea E. Colina Blanco, Stephan Clemens
Rok vydání:	2022
Předmět:	Carcinogens Cacodylic Acid Humans Oryza General Chemistry General Agricultural and Biological Sciences Arsenicals Arsenic
Zdroj:	Journal of Agricultural and Food Chemistry. 70:9610-9618
ISSN:	1520-5118 0021-8561
DOI:	10.1021/acs.jafc.2c02425
Popis:	Arsenic (As) occurrence in rice is a serious human health threat. Worldwide, regulations typically limit only carcinogenic inorganic As, but not possibly carcinogenic dimethylated oxyarsenate (DMA). However, there is emerging evidence that "DMA", determined by routine acid-based extraction and analysis, hides a substantial share of dimethylated thioarsenates that have similar or higher cytotoxicities than arsenite. Risk assessments characterizing the in vivo toxicity of rice-derived dimethylated thioarsenates are urgently needed. In the meantime, either more sophisticated methods based on enzymatic extraction and separation of dimethylated oxy- and thioarsenates have to become mandatory or total As should be regulated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4227d10cb39c3ec27542af6a5532ae03 https://doi.org/10.1021/acs.jafc.2c02425 Zobrazit plný text záznamu