LYMPHOCYTE SUBPOPULATIONS ANALYSIS IN PERIPHERAL BLOOD IN POLYMYALGIA RHEUMATICA/GLANT CELL ARTERITIS
| Autor: | Carlo Salvarani, E Beltrandi, Luigi Boiardi, Pierluigi Macchioni, M. Casadei-Maldini, Rita Mancini, F. Ross, Italo Portioli |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Pathology medicine.medical_specialty CD8 Antigens Lymphocyte CD3 Giant Cell Arteritis CD4-CD8 Ratio Aged Aged 80 and over Female Humans Leukocyte Count Lymphocyte Subsets Middle Aged Polymyalgia Rheumatica Prednisone Prospective Studies Polymyalgia rheumatica Lymphocyte subpopulations Rheumatology immune system diseases Internal medicine 80 and over medicine Pharmacology (medical) Arteritis biology business.industry T lymphocyte medicine.disease Peripheral blood Giant cell arteritis Endocrinology medicine.anatomical_structure CD4 Antigens biology.protein CD5 business CD8 |
| Zdroj: | Rheumatology. 32:666-670 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/32.8.666 |
| Popis: | The phenotypic characteristics of peripheral blood lymphocytes were investigated in 22 patients suffering from active polymyalgia rheumatica/giant cell arteritis (PMR/GCA) prior to steroid treatment. We observed a significant reduction in the absolute number and the relative percentage of CD4-, CD8+ and CD3+, CD16+ and/or CD56+ cells compared to controls. Fifteen patients were investigated prospectively over a 6-month period of prednisone therapy. At the end of the study CD4-CD8+ cells had increased significantly compared to baselines, CD3+ CD16+ and/or CD56+ cells remained significantly lower when compared to controls. We did not observe any abnormalities in the absolute number and percentage of HLA-DR+ T lymphocytes, CD5+ B cells and NK cell phenotypes before or during steroid treatment. Our study confirms that there was significant increase in the absolute number of CD8+ T cells during steroid treatment in the PMR/GCA patients, but indicates the persistence of an immunological alteration despite the control of disease manifestations. |
| Databáze: | OpenAIRE |
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