Comparison of nerve regeneration through different types of neural prostheses
| Autor: | George M. Strain, Karen L. Gibson, Nancy Satterlee, Laura Remson, Joanne K. Daniloff, Andrea A. Smith |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Time Factors Fluorescent Antibody Technique Connective tissue Biocompatible Materials Walking Electromyography Polypropylenes medicine Animals Gait Polyglactin 910 Nerve allograft medicine.diagnostic_test business.industry Regeneration (biology) Rats Inbred Strains Equipment Design Prostheses and Implants Surgical Mesh Silastic Sciatic Nerve Axons Nerve Regeneration Rats Surgery Surgical mesh medicine.anatomical_structure Silicone Elastomers Female Sciatic nerve Polyethylenes Intubation business |
| Zdroj: | Microsurgery. 12:80-85 |
| ISSN: | 1098-2752 0738-1085 |
| DOI: | 10.1002/micr.1920120205 |
| Popis: | Rat sciatic nerve regeneration through three synthetic neural prostheses was compared with regeneration through nerve allografts. The synthetic prostheses were either nonpermeable nonabsorbable (Silastic), permeable absorbable (polyglactin mesh), or permeable nonabsorbable (polypropylene mesh). Animals were evaluated at 10, 24, and 90 days. Functional analysis of nerve regeneration was performed by noninvasive methods: electromyography and walking tracks. Nerve tissue was examined with routine histologic and immunofluorescent techniques. A compressive neuropathy developed with the use of the Silastic implant. A neutrophilic inflammatory infiltrate was consistently associated with implantation of the polyglactin mesh. A strong connective tissue response was noted around the polypropylene mesh. Early recovery of nerve function was seen with the Silastic implants, however, overall nerve function was best in the nerve allograft and polypropylene mesh groups. Polyglactin implantation increases the local inflammatory response and should not be used for nerve anastomoses. If Silastic entubulation is used, it should be removed between 24 and 90 days. |
| Databáze: | OpenAIRE |
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