Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study
| Autor: | Anke Koller, Peter R. Mazal, Andrea Haitel, Martin Susani, Martin Stichenwirth, Sabine Blach |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Chromophobe cell Aquaporins Kidney urologic and male genital diseases Pathology and Forensic Medicine Renal neoplasm Cytokeratin Biomarkers Tumor medicine Adenoma Oxyphilic Humans Carcinoma Renal Cell Neoplasm Staging Aquaporin 2 Tissue microarray Aquaporin 1 Papillary renal cell carcinomas urogenital system business.industry Keratin-7 PAX2 Transcription Factor medicine.disease Immunohistochemistry Carcinoma Papillary Kidney Neoplasms DNA-Binding Proteins Tissue Array Analysis Keratin 7 Blood Group Antigens Keratins Adenocarcinoma Neprilysin business Clear cell Adenocarcinoma Clear Cell Transcription Factors |
| Zdroj: | Modern Pathology. 18:535-540 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.3800320 |
| Popis: | Diagnostic use of antibodies against aquaporin water channel proteins and PAX-2, a nuclear transcription factor in renal development, was tested in 202 renal neoplasms, using tissue microarray technique. Immunohistochemistry for aquaporin-1, aquaporin-2, PAX-2, CD10, and cytokeratin 7 was performed on 102 clear cell renal cell carcinomas, 44 papillary renal cell carcinomas (among them 34 type 1 and 10 type 2), 24 chromophobe renal cell carcinomas, three collecting duct carcinomas (carcinomas of the collecting ducts of Bellini), and 29 oncocytomas. Aquaporin-1 expression was found in clear cell renal cell carcinomas and papillary renal cell carcinomas of both types (78 and 73%, respectively), but not in chromophobe renal cell carcinomas, collecting duct carcinomas, and oncocytomas. Aquaporin-2 expression was not seen in any of the tested tumors. PAX-2 and CD10 was found in the majority of clear cell renal cell carcinomas (88 and 85%, respectively) but only in few papillary renal cell carcinomas, chromophobe renal cell carcinomas and oncocytomas. Decrease or loss of aquaporin-1 and PAX-2 was shown in higher grades compared to lower grades of clear cell renal cell carcinomas (P |
| Databáze: | OpenAIRE |
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