Clinical practice guidelines on the diagnosis and management of polycystic ovary syndrome : a systematic review and quality assessment study
| Autor: | Vikram Sinai Talaulikar, Ephia Yasmin, Laura Bevington, Gerrad Conway, Maria Fisher, Melanie C. Davies, Bassel H. Al Wattar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Quality Assurance Health Care Endocrinology Diabetes and Metabolism Clinical Biochemistry Psychological intervention MEDLINE 030209 endocrinology & metabolism Context (language use) Disease Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Medicine Humans Intensive care medicine 030219 obstetrics & reproductive medicine Evidence-Based Medicine business.industry Biochemistry (medical) Disease Management Guideline Mental health Polycystic ovary Practice Guidelines as Topic Female RG business Risk assessment RA Polycystic Ovary Syndrome |
| ISSN: | 0021-972X |
| Popis: | Context Clinical practice guidelines (CPGs) are key instruments to implement the practice of evidence-based medicine. We aimed to evaluate the methodological quality and variations in CPGs recommendations on the diagnosis and management of polycystic ovary syndrome (PCOS). Evidence Acquisition We searched MEDLINE, EMBASE, and CENTRAL until December 2020 for all evidence-based CPGs and consensus statements on PCOS. We extracted data in duplicate to map clinical recommendations across prespecified disease domains and assessed CPGs methodological quality of using the Appraisal of Guidelines, Research & Evaluation II tool. Evidence Synthesis We included 13 PCOS CPGs published between 2007 and 2018. CPGs recommendations were mostly focused on screening for and managing metabolic disease (12/13, 92%), followed by cardiovascular risk assessment (10/13, 77%). Mental health (8/13, 62%) and diagnosis in adolescents (7/13, 54%) were the least reported domains. Most CPGs had a high quality for scope and purpose description (12/13, 92%) while stakeholder’s involvement and applicability of recommendations to clinical practice were appropriate in only 2 CPGs (2/13, 15%). We identified inconsistency in recommendations on PCOS diagnosis in adolescents, optimal lifestyle interventions, hirsutism and acne treatments, interventions to reduce the risk of ovarian hyperstimulation syndrome, the frequency and screening criteria for metabolic and cardiovascular disease, and optimal screening tools for mental health illness in women with PCOS. Conclusion Current CPGs on the diagnosis and management of PCOS vary in their scope and methodological quality, which may hinder evidence translation into clinical practice. We identified disease domains with existing evidence gap to guide future research and guideline updates. |
| Databáze: | OpenAIRE |
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