Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature
| Autor: | Anja Christina Koop, Joerg Heeren, Ioannis Evangelakos, Clara John, Klaus Tödter, Mira J Pauly, Anna Worthmann, Julia K Rohde, Ludger Scheja, Paul Pertzborn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Inulin lcsh:TX341-641 Butyrate Article Bile Acids and Salts Feces Mice 03 medical and health sciences chemistry.chemical_compound Cholestasis Internal medicine Brown adipose tissue medicine Animals chemistry.chemical_classification bile acids 030109 nutrition & dietetics Nutrition and Dietetics inulin Temperature Bilirubin Metabolism Fatty Acids Volatile medicine.disease Housing Animal Mice Inbred C57BL Cholesterol 030104 developmental biology Endocrinology medicine.anatomical_structure Liver chemistry Hepatocyte Dietary Supplements Propionate Fermentation Chemical and Drug Induced Liver Injury cholestasis lcsh:Nutrition. Foods and food supply short chain fatty acids Food Science fiber |
| Zdroj: | Nutrients Volume 12 Issue 10 Nutrients, Vol 12, Iss 3200, p 3200 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12103200 |
| Popis: | Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent studies suggest that long-term supplementation with fibers causes changes in hepatic bile acid metabolism, hepatocyte damage, and hepatocellular cancer in dysbiotic mice. Alterations in hepatic bile acid metabolism have also been reported after cold-induced activation of brown adipose tissue. Here, we aim to investigate the effects of short-term dietary inulin supplementation on liver cholesterol and bile acid metabolism in control and cold housed specific pathogen free wild type (WT) mice. We found that short-term inulin feeding lowered plasma cholesterol levels and provoked cholestasis and mild liver damage in WT mice. Of note, inulin feeding caused marked perturbations in bile acid metabolism, which were aggravated by cold treatment. Our studies indicate that even relatively short periods of inulin consumption in mice with an intact gut microbiome have detrimental effects on liver metabolism and function. |
| Databáze: | OpenAIRE |
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