| Autor: |
O O, Ayandipo, O J, Adepoju, G O, Ogun, O O, Afuwape, O Y, Soneye, I B, Ulasi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
African Health Sciences; Vol. 22 No. 1 (2022); 115-24 |
| ISSN: |
1680-6905 |
| DOI: |
10.4314/ahs.v22i1.15 |
| Popis: |
Background: Surgical resection margins (RM), axillary nodal involvement and lymph node ratio (LNR) determine loco-regional control (LRC) in breast cancer management. Late presentation precludes breast conservation therefore surgical option is usually mastectomy and adjuvant chemoradiation minimize loco-regional recurrence (LRR). Objective: We investigated the prognostic role of lymph nodes positive for malignancy (pN), LNR and RM on LRR of breast cancer in a tertiary hospital in Ibadan, Nigeria. Methods: Longitudinal cohort study of 225 females with breast carcinoma managed and followed up for 5-years with end point of LRR or not. Chi-square test and logistic regression analysis were used to evaluate the interaction of resection margin and proportion of metastatic lymph nodes with LRR. The receiver-operator curve was plotted to determine the proportion of metastatic lymph nodes which predicted LRR. Results: Ninety-nine percent had modified radical mastectomy and 163 (72.4%) had negative resection margins. A mean of 11 axillary lymph nodes were harvested at surgery. The age, positive resection margin and number of harvested nodes with malignant cells are associated with LRR. The overall 5-year LRR rate was 16%. Conclusion: LRR is dependent on lymph node involvement as well as and tumor aggressiveness. Keywords: Recurrence; breast cancer; Ibadan; Axillary nodes; resection margins. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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