Lipid peroxidation, antioxidant activities and stress protein (HSP72/73, GRP94) expression in kidney and liver of rats under lithium treatment
| Autor: | Mohamed Salah Allagui, Abdelfettah Elfeki, Jean-Claude Murat, Ezzedine Bourogaa, Françoise Croute, Monji Saoudi, Riadh Nciri |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Lithium (medication) Physiology Glucose-regulated protein Gene Expression HSP72 Heat-Shock Proteins Kidney Thiobarbituric Acid Reactive Substances Biochemistry Antioxidants Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Lithium Carbonate Antimanic Agents Internal medicine medicine TBARS Animals Urea HSP70 Heat-Shock Proteins Renal Insufficiency Rats Wistar biology Lithium carbonate Membrane Proteins Kidney metabolism General Medicine Rats Oxidative Stress medicine.anatomical_structure Endocrinology Liver chemistry Creatinine biology.protein Lipid Peroxidation medicine.drug |
| Zdroj: | Journal of Physiology and Biochemistry. 68:11-18 |
| ISSN: | 1877-8755 1138-7548 |
| DOI: | 10.1007/s13105-011-0113-3 |
| Popis: | The present work was aimed at studying the effects of a subchronic lithium treatment on rat liver and kidneys, paying attention to the relationship between lithium toxicity, oxidative stress, and stress protein expression. Male rats were submitted to lithium treatment by adding 2 g of lithium carbonate/kg of food for different durations up to 1 month. This treatment led to serum concentrations ranging from 0.5 mM (day 7) to 1.34 mM (day 28) and renal insufficiency highlighted by an increase of blood creatinine and urea levels and a decrease of urea excretion. Lithium treatment was found to trigger an oxidative stress both in kidney and liver, leading to an increase of lipid peroxidation level (TBARS) and of superoxide dismutase and catalase activities. Conversely, glutathione peroxidase activity was reduced. Constitutive HSP73 (heat shock protein 73) expression was not modified by lithium treatment, whereas inducible HSP72 was down-regulated in kidney. GRP94 (glucose regulated protein 94) appeared as two isoforms of 92 and 98 kDa: the 98-kDa protein being overexpressed in kidney by lithium treatment whereas 92-kDa protein was underexpressed both in kidney and liver. |
| Databáze: | OpenAIRE |
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