Protective effect of Copaifera langsdorffii oleo-resin against acetic acid-induced colitis in rats
| Autor: | Vietla Satyanarayana Rao, Luilma A. Gurgel, Flávia A. Santos, E.R. Silveira, Regilane M. Silva, L. A. F. Paiva, E. T. de Sousa |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pharmacology chemistry.chemical_compound Edema Drug Discovery Copaiba medicine Animals Colitis Rats Wistar Acute colitis Acetic Acid Diminution biology Balsams business.industry Plant Extracts Fabaceae biology.organism_classification Malondialdehyde medicine.disease Copaifera langsdorffii Rats chemistry Myeloperoxidase biology.protein Plant Bark medicine.symptom business |
| Zdroj: | Journal of ethnopharmacology. 93(1) |
| ISSN: | 0378-8741 |
| Popis: | The oleo-resin from Copaifera langsdorffii (Leguminosae) was evaluated in rats on acetic acid-induced colitis. Rats were pretreated orally (15 and 2 h) or rectally (2 h) before the induction of colitis with copaiba oleo-resin (200 and 400 mg/kg) or vehicle (1 ml, 2% Tween 80). Colitis was induced by intracolonic instillation of a 2 ml of 4% (v/v) acetic acid solution and 24 h later, the colonic mucosal damage was analyzed for the severity of macroscopic colonic damage, myeloperoxidase (MPO) activity, and malondialdehyde levels. A significant reduction in gross damage score and in wet weight/length ratio of colonic tissue were evident in test substance-pretreated animals as compared to vehicle or oleo-resin alone-treated controls. This effect was confirmed biochemically by a reduction in colonic myeloperoxidase activity, the marker of neutrophilic infiltration, and by a marked decrease in malondialdehyde level, an indicator of lipoperoxidation. Furthermore, microscopical examination revealed the diminution of inflammatory cell infiltration, and submucosal edema in the colon segments of rats treated with copaiba oleo-resin. The data indicate the protective effect of copaiba oleo-resin in the animal model of acute colitis possibly through an antioxidant and or anti-lipoperoxidative mechanism. |
| Databáze: | OpenAIRE |
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