Bioresponsive microlasers with tunable lasing wavelength
| Autor: | Zhiyi Yuan, Xiaotian Tan, Shilun Feng, Xin Cheng, Xudong Fan, Chaoyang Gong, Xuerui Gong, Yu-Cheng Chen |
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| Přispěvatelé: | School of Electrical and Electronic Engineering, School of Chemical and Biomedical Engineering |
| Rok vydání: | 2021 |
| Předmět: |
Optics and Photonics
Sensitive Detection Materials science Physics::Optics Biointerface 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention Molecular level law General Materials Science Range (particle radiation) business.industry Lasers 021001 nanoscience & nanotechnology Laser 0104 chemical sciences Wavelength Lasing wavelength Electrical and electronic engineering [Engineering] Optoelectronics 0210 nano-technology business Biological imaging Lasing threshold |
| Zdroj: | Nanoscale. 13:1608-1615 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/d0nr07921a |
| Popis: | Lasing particles are emerging tools for amplifying light-matter interactions at the biointerface by exploiting its strong intensity and miniaturized size. Recent advances in implementing laser particles into living cells and tissues have opened a new frontier in biological imaging, monitoring, and tracking. Despite remarkable progress in micro- and nanolasers, lasing particles with surface functionality remain challenging due to the low mode-volume while maintaining a high Q-factor. Herein, we report the novel concept of bioresponsive microlasers by exploiting interfacial energy transfer based on whispering-gallery-mode (WGM) microdroplet cavities. Lasing wavelengths were manipulated by energy transfer-induced changes of a gain spectrum resulting from the binding molecular concentrations at the cavity surface. Both protein-based and enzymatic-based interactions were demonstrated, shedding light on the development of functional microlasers. Finally, tunable lasing wavelengths over a broad spectral range were achieved by selecting different donor/acceptor pairs. This study not only opens new avenues for biodetection, but also provides deep insights into how molecules modulate laser light at the biointerface, laying the foundation for the development of smart bio-photonic devices at the molecular level. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University This research is supported by A*STAR under its AME IRG Grant (Project No. A20E5c0085). We would also like to thank the lab support from the Centre of Bio-Devices and Signal Analysis and Internal Grant NAP SUG - M4082308.040 from NTU. |
| Databáze: | OpenAIRE |
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