Ageing opioid users’ increased risk of methadone-specific death in the UK
| Autor: | Matthias Pierce, J. Roy Robertson, Sheila M. Bird, Tim Millar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Aging Adolescent Databases Factual 030508 substance abuse Medicine (miscellaneous) Poison control Suicide prevention Occupational safety and health Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Injury prevention Journal Article Humans Medicine 030212 general & internal medicine business.industry Health Policy Hazard ratio Human factors and ergonomics Middle Aged Opioid-Related Disorders United Kingdom Analgesics Opioid Heroin Cohort Female 0305 other medical science business RA Methadone Demography medicine.drug |
| Zdroj: | Pierce, M, Millar, T, Robertson, J R & Bird, S M 2018, ' Ageing opioid users' increased risk of methadone-specific death in the UK ', The International Journal of Drug Policy, vol. 55, pp. 121-127 . https://doi.org/10.1016/j.drugpo.2018.02.005 Pierce, M, Millar, T, Robertson, J R & Bird, S M 2018, ' Ageing opioid users' increased risk of methadone-specific death in the UK ', International Journal of Drug Policy, vol. 55, pp. 121-127 . https://doi.org/10.1016/j.drugpo.2018.02.005 |
| ISSN: | 0955-3959 |
| DOI: | 10.1016/j.drugpo.2018.02.005 |
| Popis: | BACKGROUND: The first evidence that the hazard ratio (HR) for methadone-specific death rises more steeply with age-group than for all drug-related deaths (DRDs) came from Scotland's cohort of 33,000 methadone-prescription clients. We aim to examine, for England, whether illicit opioid users' risk of methadone-specific death increases with age; and to pool age-related HRs for methadone-specific deaths with those for Scotland's methadone-prescription clients.METHODS: The setting is all services in England that provide publicly-funded, structured treatment for illicit opioid users, the methodology linkage of the English National Drug Treatment Monitoring System and mortality database, and key measurements are DRDs, methadone-specific DRDs, or heroin-specific DRDs, by age-group and gender, with proportional hazards adjustment for substances used, injecting status and periods in/out of treatment.RESULTS: Linkage was achieved for 129,979 adults receiving prescribing treatment modalities for opioid dependence during April 2005 to March 2009 and followed-up for 378,009 person-years (pys). There were 1,266 DRDs: 271 methadone-specific (7 per 10,000 pys: irrespective of gender) and 473 heroin-specific (15 per 10,000 pys for males, 7 for females). Methadone-specific DRD-rate per 10,000 person-years was 3.5 (95% CI: 2.7-4.4) at 18-34 years, 8.9 (CI: 7.3-10.5) at 35-44 years and 18 (CI: 13.8-21.2) at 45+ years; heroin-specific DRD-rate was unchanged with age. Relative to 25-34 years, pooled HRs for UK clients' methadone-specific deaths were: 0.87 at CONCLUSION: International testing and explanation are needed of UK's sharp age-related increase in the risk of methadone-specific death. Clients should be alerted that their risk of methadone-specific death increases as they age. |
| Databáze: | OpenAIRE |
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