MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3
| Autor: | Pei-Yi Tan, Hua-Nan Li, Shi-Wei Chai, Liu-Jing Wen |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell growth business.industry Clinical Biochemistry Biomedical Engineering Bioengineering Cell Biology medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Apoptosis 030220 oncology & carcinogenesis Cancer cell Cancer research Medicine Original Article Breast cancer cells skin and connective tissue diseases business Normal control Human breast Biotechnology E2F2 |
| Zdroj: | Cytotechnology |
| ISSN: | 1573-0778 0920-9069 |
| Popis: | MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer. |
| Databáze: | OpenAIRE |
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