The Hantzsch reaction for nitrogen-13 PET: preparation of [13N]nifedipine and derivatives
| Autor: | Michelle T. Ma, Antony D. Gee, Fahad Al-Salemee, Julia E. Blower |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry Metals and Alloys General Chemistry 010402 general chemistry Condensation reaction 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Labelling Materials Chemistry Ceramics and Composites Pet tracer |
| Zdroj: | Blower, J, Ma, M, Al-Salemee, F & Gee, T 2021, ' The Hantzsch reaction for nitrogen-13 PET: preparation of [ 13 N]nifedipine and derivatives ', Chemical communications (Cambridge, England), vol. 57, no. 40, pp. 4962-4965 . https://doi.org/10.1039/d1cc00495f |
| DOI: | 10.1039/d1cc00495f |
| Popis: | Nitrogen-13 is an attractive but under-used PET radionuclide for labelling molecules of biological and pharmaceutical interest, complementing other PET radionuclides. Its short half-life (t1/2 = 9.97 min) imposes synthetic challenges, but we have expanded the hitherto limited pool of 13N labelling strategies and tracers by adapting the multicomponent Hantzsch condensation reaction to prepare a library of 13N-labelled 1,4-dihydropyridines from [13N]ammonia, including the widely-used drug nifedipine. This represents a key advance in 13N PET radiochemistry, and will serve to underpin the renewed interest in clinical opportunities offered by short-lived PET tracers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|