Administration of Subcutaneous Furosemide in Elastomeric Pump vs. Oral Solution for the Treatment of Diuretic Refractory Congestion
| Autor: | Raquel López-Vilella, Luis Almenar Bonet, Emilio Monte Boquet, Julio Núñez Villota, Luis Martínez Dolz, Ignacio Sánchez-Lázaro, Inmaculada Husillos Tamarit, Víctor Donoso Trenado |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Administration Oral Infusions Subcutaneous chemistry.chemical_compound Pharmacotherapy Refractory Furosemide Weight loss Internal Medicine medicine Humans Diuretics Infusion Pumps Heart Failure Creatinine business.industry medicine.disease Treatment Outcome chemistry Heart failure Anesthesia Functional status medicine.symptom Diuretic Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | High Blood Pressure & Cardiovascular Prevention. 28:589-596 |
| ISSN: | 1179-1985 1120-9879 |
| Popis: | The most common symptom in heart failure (HF) is congestion, which can be refractory to diuretic treatment. To verify whether, in patients with advanced HF and diuretic resistance, subcutaneous furosemide or furosemide in an oral solution can improve the clinical-analytical status. From 2018 to 2020, 27 consecutive outpatients with diuretic resistance, not candidates for other alternatives, were recruited. Patients were treated either with subcutaneous furosemide in elastomeric pump (n: 10) or with oral solution (n: 17) for 5 days. The functional status (NYHA) improved with subcutaneous administration (predose: 3.8 ± 0.5 vs. postdose: 3.1 ± 0.7; p: 0.02) and oral solution (predose: 3.7 ± 0.3 vs. postdose: 2.5 ± 0.7; p: 0.0001). Weight loss was greater with the oral solution (predose: 85.5 ± 19.5 vs. postdose: 81.3 ± 18.8Kg; p: 0.0001) than subcutaneous (predose: 81.6 ± 15.9 vs. postdose: 80.4 ± 15.1kg; p: 0.16). Creatinine showed a non-significant increase in both groups. The number of hospital visits showed no difference between both options. The administration of furosemide, both subcutaneously by elastomeric pump or drinking the oral solution, is effective for the treatment of congestion in advanced HF refractory to diuretic treatment. |
| Databáze: | OpenAIRE |
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