Multi-scale simulation of early kidney branching morphogenesis
| Autor: | Yunqi Wang, Hong Zhang, Wenran Cai, Tianzhi Luo, Jicong Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Surface (mathematics)
Physics 0303 health sciences Similarity (geometry) Scale (ratio) Continuous modelling Biophysics Kidney development Cell Biology Kidney Models Biological Mice 03 medical and health sciences 0302 clinical medicine Exponential growth Intersection Structural Biology Feature (computer vision) Morphogenesis Animals Biological system Molecular Biology 030217 neurology & neurosurgery Signal Transduction 030304 developmental biology |
| Zdroj: | Physical Biology. 18:026005 |
| ISSN: | 1478-3975 1478-3967 |
| Popis: | An important feature of the branch morphogenesis during kidney development is the termination of the tips on the outer surface of a kidney. This feature requires the avoidance of the intersection between the tips and existing ducts inside the kidney. Here, we started from a continuous model and implemented the coarse grained rules into a fast and discrete simulations. The ligand–receptor-based Turing mechanism suggests a repulsion that decreases exponentially with distance between interacting branches, preventing the intersection between neighboring branches. We considered this repulsive effect in numerical simulations and successfully reproduce the key features of the experimentally observed branch morphology for an E15.5 kidney. We examine the similarity of several geometrical parameters between the simulation results and experimental observations. The good agreement between the simulations and experiments suggests that the concentration decay caused by the absorption of glial cell line derived neurotrophic factor might be the key factor to affect the geometry in early kidney development. |
| Databáze: | OpenAIRE |
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