Management and clinical outcomes of Lyme disease in acute care facilities in 2 endemic regions of Quebec, Canada: a multicentre retrospective cohort study

Autor:	Jean B, Musonera, Louis, Valiquette, Geneviève, Baron, François, Milord, Dominique, Marcoux, Karine, Thivierge, Samuel, Bedard-Dallaire, Andrée A, Pelletier, Raphaël, Lachance, Jeremy, Bourget, Catherine, Simard, Emmanuelle, Cantin, Farhad, Abbasi, Louis-Patrick, Haraoui, Alex, Carignan
Rok vydání:	2022
Předmět:	Adult Aged 80 and over Canada Lyme Disease Post-Lyme Disease Syndrome Adolescent Quebec General Medicine Middle Aged Cohort Studies Young Adult Child Preschool Humans Prospective Studies Child Aged Retrospective Studies
Zdroj:	CMAJ Open. 10:E570-E576
ISSN:	2291-0026
Popis:	Despite increases in cases of Lyme disease, little is known about the management and clinical course of the disease in Canada. We aimed to describe the management and clinical course of Lyme disease in patients treated in acute care facilities in Quebec and to assess adherence to the 2006 Infectious Diseases Society of America (IDSA) guideline.This retrospective multicentre cohort study included pediatric and adult patients with serologically confirmed Lyme disease treated in acute care facilities (12 community hospitals and 2 tertiary care centres) of 2 endemic regions of Quebec (Estrie and Montérégie), from 2004 to 2017. We considered drug choice, prescribed dose and treatment duration in assessing adherence of prescriptions to the 2006 IDSA guideline. The main outcome was complete resolution of symptoms at 3 months after the initiation of treatment.We included 272 patients from 14 institutions (age range 3-87 yr). Early disseminated Lyme disease (140 patients [51%]) was predominant. Adherence to the IDSA guideline was observed in 235 (90%) of the 261 cases with complete information, and adherence was stable over time (2004-2013: 57/64 [89%]; 2014-2015: 64/71 [90%]; 2016-2017: 114/126 [90%];We observed clinical resolution of Lyme disease in 99% of the patients, and most treatments (90%) complied with the 2006 IDSA guideline. The incidence of post-treatment Lyme disease syndrome increased over the study period, warranting further prospective studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4214f21d0aeede0da7203413bd5372e6 https://doi.org/10.9778/cmajo.20210063 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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