Low risk of treatment resistance in Down syndrome with Kawasaki disease
| Autor: | Shohei Ogata, Tatsuro Izumi, Junko Shiono, Hiroyuki Moriuchi, Terufumi Goushi, Tsutomu Saji, Masahiro Ishii, Hiroyuki Ida, Keiji Tsuchiya, Masato Yokozawa, Tatsuya Kawano, Masako Fujiwara, Fukiko Ichida, Masae Ono, Hideki Motomura, Yoichi Kawamura, Shinichi Takatsuki, Mio Taketazu, Shiro Tsuchiya |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Down syndrome Coronary Vessel Anomalies Drug Resistance Drug resistance Comorbidity Mucocutaneous Lymph Node Syndrome 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Internal medicine Prevalence Medicine Humans Immunologic Factors Child Retrospective Studies Aspirin biology business.industry Medical record Immunoglobulins Intravenous Infant Retrospective cohort study medicine.disease 030104 developmental biology Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health biology.protein Kawasaki disease Female Antibody Down Syndrome business 030215 immunology medicine.drug |
| Zdroj: | Pediatrics international : official journal of the Japan Pediatric Society. 59(12) |
| ISSN: | 1442-200X |
| Popis: | BACKGROUND A Japanese nationwide survey has reported that Down syndrome (DS) is a less-frequently occurring comorbidity in Kawasaki disease (KD). Although altered immune responses are frequently observed in DS, no studies have focused on the treatment response and risk for coronary artery abnormalities (CAA) in DS patients with KD. The aim of this study was therefore to evaluate the clinical manifestations, treatment response and prevalence of CAA in DS with KD. METHODS We retrospectively reviewed the medical records of DS patients with KD from 2005 through 2012. The survey questionnaires were sent to facilities nationwide, and clinical data regarding KD in DS were collected. A control group consisted of non-DS patients with KD who were managed at Toho University. RESULTS Of the 94 233 children diagnosed with acute KD from 2005 to 2012, 16 children with acute KD also had DS (0.017%). The DS-KD patients were significantly older than the non-DS patients (median, 8 years vs 1 year, P |
| Databáze: | OpenAIRE |
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