Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp
| Autor: | Tobias Mantel, Christian Dresel, Bernhard Haslinger, Jona Kräenbring, Angela Jochim, Tobias Meindl, Gina Gora-Stahlberg, Maria Berndt, Yong Li |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Premotor cortex S2 secondary somatosensory cortex SMG supramarginal gyrus ROI region of interest PPN premotor parietal network Brain mapping lcsh:RC346-429 PAT writer's cramp patients Functional connectivity 0302 clinical medicine Cerebellum Parietal Lobe Basal ganglia Neural Pathways TIV total intracranial volume Resting state SPC superior parietal cortex IC independent component WC writer's cramp Brain Mapping medicine.diagnostic_test SMA supplementary motor area Writer's cramp Parietal lobe Motor Cortex Regular Article v/dSMN ventral/dorsal sensorimotor network Middle Aged Magnetic Resonance Imaging ICA independent component analysis ddc ICN intrinsic connectivity network Dystonia medicine.anatomical_structure Neurology Dystonic Disorders FWHM full width at half maximum lcsh:R858-859.7 Female Sensorimotor Cortex Psychology Adult PMd/v dorsal/ventral premotor cortex CONTR healthy controls Cognitive Neuroscience FC functional connectivity lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences ADDS arm dystonia disability scale medicine Humans Radiology Nuclear Medicine and imaging WCRS writer's cramp rating scale lcsh:Neurology. Diseases of the nervous system M1 primary motor cortex PCA principal component analysis Resting state fMRI CN cerebellar network SM1 primary sensorimotor cortex FoV field of view GM grey matter medicine.disease BOLD blood oxygen level-dependent FHD focal hand dystonia IPS intraparietal sulcus BGN basal ganglia network 030104 developmental biology rsfMRI resting state functional magnetic resonance imaging S1 primary somatosensory cortex Neurology (clinical) Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Dystonic disorder |
| Zdroj: | NeuroImage: Clinical, Vol 17, Iss, Pp 137-144 (2018) NeuroImage : Clinical |
| Popis: | Background Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in the disease. Objective To clarify and extend the knowledge of underlying changes by investigating functional connectivity (FC) in intrinsic connectivity networks with putative sensorimotor function at rest in an increased number of study subjects. Methods Resting-state functional magnetic resonance imaging with independent component analysis was performed in 26/27 writer's cramp patients/healthy controls, and FC within and between resting state networks with putative sensorimotor function was compared. Additionally, voxel-based morphometry was carried out on the subjects' structural images. Results Patients displayed increased left- and reduced right-hemispheric primary sensorimotor FC in the premotor-parietal network. Mostly bilaterally altered dorsal/ventral premotor FC, as well as altered parietal FC were observed within multiple sensorimotor networks and showed differing network-dependent directionality. Beyond within-network FC changes and reduced right cerebellar grey matter volume in the structural analysis, the positive between-network FC of the cerebellar network and the basal ganglia network was reduced. Conclusions Abnormal resting-state FC in multiple networks with putative sensorimotor function may act as basis of preexisting observations made during task-related neuroimaging. Further, altered connectivity between the cerebellar and basal ganglia network underlines the important role of these structures in the disease. Highlights • Investigation of FC changes in various sensorimotor ICNs at rest in writer's cramp. • We saw multiple, network-specific FC changes in primary/higher sensorimotor cortices. • This may act as basis of the varying nature of sensorimotor changes during task-fMRI. • Further, findings supporting disrupted cerebellar-basal ganglia interaction were made. • An additional morphometric analysis demonstrated structural cerebellar abnormality. |
| Databáze: | OpenAIRE |
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