Synthesis of Novel Structurally Simplified Estrogen Analogues
| Autor: | Carsten A. Vock, Ilga K. Krimmelbein, Christiane Gatz, Kazi Mohammed Didarul Islam, J. Matthias Wiegand, Linda Nacke, Lutz F. Tietze, Tokala Ramachandar |
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| Rok vydání: | 2008 |
| Předmět: |
Estradiol
Estrone 010405 organic chemistry Chemistry Stereochemistry medicine.medical_treatment Organic Chemistry Molecular Conformation Sonogashira coupling Stereoisomerism General Chemistry Estrogen analogues 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Steroid Small Molecule Libraries medicine |
| Zdroj: | Chemistry - A European Journal. 14:3670-3679 |
| ISSN: | 1521-3765 0947-6539 |
| DOI: | 10.1002/chem.200701600 |
| Popis: | A library of 17 novel estrogen analogues 3 and 4 containing different substituents at rings A and D (steroid nomenclature) was prepared in a five- to seven-step synthesis. The key transformation is a Sonogashira-coupling of cyclic vinyl iodides of type 7 or 8 with phenylacetylenes of type 9. Reduction of the keto function in 3 led to the estradiol analogue 5. |
| Databáze: | OpenAIRE |
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