CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-γ production and increased sensitivity to dexamethasone
| Autor: | Jeroen Visser, B. Hinloopen, Emile Brommer, Lex Nagelkerken, Bep Blauw, E. Ronald de Kloet, Cornelis Kluft |
|---|---|
| Přispěvatelé: | TNO Preventie en Gezondheid |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
musculoskeletal diseases
Adult CD4-Positive T-Lymphocytes medicine.medical_specialty Interferon type II Helper T lymphocyte medicine.medical_treatment T cell Biology Dexamethasone Interferon-gamma Immune system Interferon Internal medicine medicine Immunology and Allergy Humans Interferon gamma Glucocorticoids Cells Cultured Pharmacology Interferon Type II Fatigue Syndrome Chronic virus diseases T lymphocyte Middle Aged Th1 Cells Infectious Diseases Endocrinology Cytokine medicine.anatomical_structure Immunology Interleukin-4 hormones hormone substitutes and hormone antagonists Cell Division medicine.drug |
| Zdroj: | Journal of Infectious Diseases, 2, 177, 451-454 Scopus-Elsevier |
| Popis: | A disturbed hypothalamus-pituitary-adrenal gland axis and alterations at the immune system level have been observed in patients with chronic fatigue syndrome (CFS). Glucocorticoids are known to modulate T cell responses; therefore, purified CD4 T cells from CFS patients were studied to determine whether they have an altered sensitivity to dexamethasone (DEX). CD4 T cells from CFS patients produced less interferon-gamma than did cells from controls; by contrast, interleukin-4 production and cell proliferation were comparable. With CD4 T cells from CFS patients (compared with cells from controls), a 10- to 20-fold lower DEX concentration was needed to achieve 50% inhibition of interleukin-4 production and proliferation, indicating an increased sensitivity to DEX in CFS patients. Surprisingly, interferon-gamma production in patients and controls was equally sensitive to DEX. A differential sensitivity of cytokines or CD4 T cell subsets to glucocorticoids might explain an altered immunologic function in CFS patients. |
| Databáze: | OpenAIRE |
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