von Willebrand factor in iris vasculature of glaucoma patients
| Autor: | Małgorzata Żaba, Romuald Wojnicz, Edyta Reichman-Warmusz, Ewa Mrukwa-Kominek, Wojciech Rokicki, Marlena Brzozowa, Dorota Wygledowska-Promieńska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure Endothelium genetic structures Glaucoma Iris Von Willebrand factor Clinical Research Internal medicine Ophthalmology hemic and lymphatic diseases von Willebrand Factor Medicine Humans Iris (anatomy) Aged biology business.industry Case-control study General Medicine Middle Aged medicine.disease Pathophysiology eye diseases medicine.anatomical_structure Endocrinology Case-Control Studies biology.protein Immunohistochemistry Female business Glaucoma Open-Angle |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND Previous reports have indicated the role of endothelium disturbances, as expressed by von Willebrand factor (vWF) release, in pathophysiology of glaucoma. The objective of this study was to investigate the vWF expression in iris vasculature of patients with primary open-angle glaucoma (POAG). MATERIAL AND METHODS Immunohistochemistry of vWF expression was performed on cryostat sections of samples collected at the time of peripheral iridectomy and controls collected from dead donors. RESULTS Twenty-seven Caucasians age 66.6±3.7 with 5.8±3.7-year history of treated PAOG and 10 controls age 62.2±1.92 with no history of glaucoma. The percentage of patients who presented normal and up-regulation of vWF phenotype expression differed statistically between examined and control groups: 48% versus 100% (p=0.035, chi-square test with Yates' correction). Sex, age, glaucoma duration, and visual field quantitative indices had no impact on vWF expression. A significant correlation between mean pre-surgery intraocular pressure and vWF expression was found (Spearman r=0.42, p=0.03). CONCLUSIONS Considering the results, it may be suggested that vWF is actively involved in the pathophysiology of glaucoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|