Down-regulation of Helios Expression in Tregs from Patients with Hypertension
| Autor: | Zhu-yue Chen, Longxian Cheng, Li-Li Jang, Yange Wang, Ding-Hang Wang, Feng Chen |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Down-Regulation HeliOS Biochemistry T-Lymphocytes Regulatory Flow cytometry 03 medical and health sciences Ikaros Transcription Factor 0302 clinical medicine Downregulation and upregulation Internal medicine Genetics medicine Humans RNA Messenger Transcription factor Pathological Cells Cultured medicine.diagnostic_test business.industry FOXP3 Forkhead Transcription Factors Plasma levels Middle Aged Interleukin-10 030104 developmental biology Cytokine Endocrinology Case-Control Studies Hypertension Female business 030215 immunology |
| Zdroj: | Current medical science. 38(1) |
| ISSN: | 2523-899X |
| Popis: | Regulatory T cells (Tregs) play a pivotal role in the pathological development of hypertension. Helios, a transcription factor from the Ikaros family, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with suppression function, however, little has been known about its role in hypertension. This study was aimed to find whether Helios+ Tregs really play a vital role in hypertension. A total of 60 hypertension patients, and 46 normotension subjects were enrolled in this study. Frequencies of different Tregs subsets in peripheral blood were measured by flow cytometry. Plasma cytokine level was determined by ELISA. The mRNA expression of Foxp3 and Helios in purified CD4+ T cells was detected by RT-PCR. Proportion of CD4+Foxp3+Helios+ Tregs was decreased significantly in patients with hypertension (62.52%±1.18% vs. 71.89%±1.03%, P |
| Databáze: | OpenAIRE |
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