To induce or not to induce: a 21st century evaluation of lung transplant immunosuppression's effect on survival

Autor:	Amy Lehman, Ahmet Kilic, Robert S.D. Higgins, Allison M. Wehr, Stephen Kirkby, Bryan A. Whitson, Amy Pope-Harman, Don Hayes
Rok vydání:	2014
Předmět:	Adult Graft Rejection Male medicine.medical_specialty Adolescent Basiliximab medicine.medical_treatment Kaplan-Meier Estimate Logistic regression Gastroenterology Young Adult Internal medicine medicine Humans Registries Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Postoperative Care Transplantation Lung Thymoglobulin Proportional hazards model business.industry Antibodies Monoclonal Immunosuppression Induction Chemotherapy Middle Aged Confidence interval Logistic Models Treatment Outcome medicine.anatomical_structure Immunology Alemtuzumab Female business Immunosuppressive Agents Lung Transplantation medicine.drug
Zdroj:	Clinical Transplantation. 28:450-461
ISSN:	0902-0063
DOI:	10.1111/ctr.12339
Popis:	Introduction The impact of induction immunosuppression on long-term survival in lung transplant recipients remains unclear. We sought to evaluate the effect of contemporary induction immunosuppression agents in lung transplant recipients’ survival, utilizing national registry data. Methods We queried the United Network for Organ Sharing registry from 2001 to 2012 for adult, deceased donor lung transplants who received no antibody-based induction (NONE) or the contemporary agents of basiliximab, alemtuzumab, thymoglobulin, antilymphocyte globulin, or antithymocyte globulin (INDUCED). Kaplan–Meier estimates of the survival and Cox proportional hazards models assessed differences in overall survival between the INDUCED and NONE groups; logistic regression models assessed differences in survival and rejection (TR1Y). Results There were 23 951 lung transplants performed with 12 858 meeting the inclusion criteria; 5713 (44%) were INDUCED. Of INDUCED agents, 62% were basiliximab and 14% alemtuzumab. Being INDUCED significantly increased overall survival (p
Databáze:	OpenAIRE
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