Intraspecific rearrangement of mitochondrial genome suggests the prevalence of the tandem duplication-random loss (TDLR) mechanism in Quasipaa boulengeri
| Autor: | Xiaomao Zeng, Yuchi Zheng, Robert W. Murphy, Yun Xia |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Mitochondrial DNA Random gene loss Mitochondrial gene order Evolution Molecular 03 medical and health sciences Phylogenetics Gene Duplication Gene Order Gene duplication Genetics Animals tRNA Gene Phylogeny Mitogenomics Sequence Deletion Gene Rearrangement biology Phylogenetic tree Intermediate mitogenomic rearrangement Gene rearrangement biology.organism_classification Phylogeography 030104 developmental biology Tandem Repeat Sequences Genome Mitochondrial Tandem exon duplication Anura Quasipaa boulengeri Research Article Biotechnology |
| Zdroj: | BMC Genomics |
| ISSN: | 1471-2164 |
| DOI: | 10.1186/s12864-016-3309-7 |
| Popis: | Background Tandem duplication followed by random loss (TDRL) is the most frequently invoked model to explain the diversity of gene rearrangements in metazoan mitogenomes. The initial stages of gene rearrangement are difficult to observe in nature, which limits our understanding of incipient duplication events and the subsequent process of random loss. Intraspecific gene reorganizations may represent intermediate states, and if so they potentially shed light on the evolutionary dynamics of TDRL. Results Nucleotide sequences in a hotspot of gene-rearrangement in 28 populations of a single species of frog, Quasipaa boulengeri, provide such predicted intermediate states. Gene order and phylogenetic analyses support a single tandem duplication event and a step-by-step process of random loss. Intraspecific gene rearrangements are not commonly found through comparison of all mitochondrial DNA records of amphibians and squamate reptiles in GenBank. Conclusions The intraspecific variation in Q. boulengeri provides insights into the rate of partial duplications and deletions within a mitogenome, and reveals that fixation and gene-distribution in mitogenomic reorganization is likely non-adaptive. Electronic supplementary material The online version of this article (doi:10.1186/s12864-016-3309-7) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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