Mutagenicity and genotoxicity of sorbic acid-amine reaction products
| Autor: | Fritsch P, Carine Ferrand, Françoise Marc, P Cassand, G. de Saint Blanquat |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Salmonella typhimurium
Preservative Chromatography Gas Magnetic Resonance Spectroscopy food.ingredient Food Handling Health Toxicology and Mutagenesis Toxicology medicine.disease_cause Mass Spectrometry Ames test chemistry.chemical_compound Food-Drug Interactions food medicine Escherichia coli Organic chemistry Humans Amines SOS Response Genetics Unsaturated fatty acid Addition reaction Potassium sorbate Mutagenicity Tests Food additive Public Health Environmental and Occupational Health Calcium sorbate General Medicine General Chemistry DNA Sorbic Acid SOS chromotest chemistry Chemistry (miscellaneous) Food Preservatives Microsomes Liver Sorbic acid Genotoxicity Food Science DNA Damage HeLa Cells Mutagens Plasmids |
| Zdroj: | Toxicology in vitro : an international journal published in association with BIBRA. 14(5) |
| ISSN: | 0887-2333 |
| Popis: | Sorbic acid as well as potassium and calcium sorbate (E202 and E203) are legally used as preservatives in numerous processed foods. Owing to its system of conjugated double bonds, sorbic acid is likely to undergo a nucleophilic attack, which may turn it into mutagenic products. The cyclic derivatives resulting from a double addition reaction between sorbic acid and various amines at two different temperatures (50 degrees C and 80 degrees C) have been analysed. A genotoxicity study has been performed with HeLa cells and plasmid DNA. A mutagenesis study has been carried out by using the Ames test. A SOS spot test and a cytotoxicity study have been realised as well. The results showed that the products involved exhibited neither mutagenic nor genotoxic activities. |
| Databáze: | OpenAIRE |
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