Non-template functions of viral RNA in picornavirus replication
| Autor: | James B. Flanegan, Sushma A. Ogram |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
DNA Replication
Genetics Viral matrix protein Picornavirus urogenital system viruses RNA-dependent RNA polymerase Picornaviridae Templates Genetic Biology RNA-Dependent RNA Polymerase Virus Replication Origin of replication Pre-replication complex biology.organism_classification Article Cell biology Viral Proteins Replication factor C Viral entry Virology RNA Viral Origin recognition complex |
| Zdroj: | Current Opinion in Virology. 1:339-346 |
| ISSN: | 1879-6257 |
| DOI: | 10.1016/j.coviro.2011.09.005 |
| Popis: | The genomic RNA of poliovirus and closely related picornaviruses perform templated and non-templated functions during viral RNA replication. The non-templated functions are mediated by cis-active RNA sequences that bind viral and cellular proteins to form RNP complexes. The RNP complexes mediate temporally dynamic, long-range interactions in the viral genome and ensure the specificity of replication. The 5’ cloverleaf (5’ CL)-RNP complex serves as a key cis-active element in all of the non-templated functions of viral RNA. The 5’CL-RNP complex is proposed to interact with the cre-RNP complex during VPgpUpU synthesis, the 3’NTR-poly(A) RNP complex during negative-strand initiation and the 3’ end negative-strand-RNP complex during positive-strand initiation. Coordinating these long-range interactions is important in regulating each step in the replication cycle. |
| Databáze: | OpenAIRE |
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