Efficacy of diffusion-weighted magnetic resonance imaging in the evaluation of extrahepatic cholestasis-related hepatic fibrosis
| Autor: | Mehmet Pul, Bekir Cagli, Sedat Alpaslan Tuncel, Güray Can, Selim Demirtaş, Turan Karaca, Mehmet Unlu, Suleyman Ayvaz, Muhammed Elmaoğlu |
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| Rok vydání: | 2015 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Extrahepatic Cholestasis digestive system Gastroenterology Sensitivity and Specificity Rats Sprague-Dawley Cholestasis Fibrosis Internal medicine medicine Effective diffusion coefficient Animals Bile duct ligation hepatic fibrosis diffusion-weighted magnetic resonance experimental extrahepatic cholestasis rat Analysis of Variance medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging General Medicine Cholestasis Extrahepatic medicine.disease digestive system diseases Rats Disease Models Animal Diffusion Magnetic Resonance Imaging End of day Liver Liver biopsy Hepatic fibrosis business |
| Zdroj: | Volume: 45, Issue: 3 686-693 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL). Materials and methods: Twenty-four rats were divided randomly into four groups: control, BDL - 3 days, BDL - 2 weeks, and BDL - 4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL - 3 days group at the end of day 3, on the rats from the BDL - 2 weeks group at the end of day 14, and on the rats from the BDL - 4 weeks at the end of day 28. Results: When fibrosis scores generated in all groups were evaluated together, a strong negative correlation was detected between fibrosis scores and apparent diffusion coefficient (ADC) values measured using b 100 and b 500. ADC values obtained using b 100 were found to be significantly higher compared to the fibrosis observed in both the BDL - 2 weeks and BDL - 4 weeks groups (P < 0.003 and P < 0.001, respectively). Conclusion: We think that DWI may be an alternative to liver biopsy for the diagnosis and staging of hepatic fibrosis with underlying extrahepatic cholestasis. |
| Databáze: | OpenAIRE |
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