Multidrug-resistant tuberculosis in the United States, 2011–2016: patient characteristics and risk factors
| Autor: | Michael P. Chen, J S Kammerer, Roque Miramontes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis 030106 microbiology Antitubercular Agents Disease Logistic regression Article Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Tuberculosis Multidrug-Resistant Odds Ratio medicine Humans 030212 general & internal medicine Genotyping biology business.industry Transmission (medicine) Odds ratio medicine.disease biology.organism_classification United States Multiple drug resistance Logistic Models Infectious Diseases business |
| Zdroj: | Int J Tuberc Lung Dis |
| ISSN: | 1027-3719 |
| DOI: | 10.5588/ijtld.19.0173 |
| Popis: | OBJECTIVE: To determine risk factors for multidrug-resistant tuberculosis (MDR-TB) and describe MDR-TB according to three characteristics: previous TB disease, recent transmission of MDR-TB, and reactivation of latent MDR-TB infection.SETTING and DESIGN: We used 2011–2016 surveillance data from the US National Tuberculosis Surveillance System and National Tuberculosis Genotyping Service and used logistic regression models to estimate risk factors associated with MDR-TB.RESULTS: A total of 615/45 209 (1.4%) cases were confirmed as MDR-TB; 111/615 (18%) reported previous TB disease; 41/615 (6.7%) were attributed to recent MDR-TB transmission; and 449/615 (73%) to reactivation. Only 12/41 (29%) patients with TB attributed to recent transmission were known to be contacts of someone with MDR-TB. For non-US-born patients, the adjusted odds ratios of having MDR-TB were 32.6 (95%CI 14.6–72.6) among those who were known to be contacts of someone with MDR-TB and 6.5 (95%CI 5.1–8.3) among those who had had previous TB disease.CONCLUSION: The majority of MDR-TB cases in the United States were associated with previous TB disease or reactivation of latent MDR-TB infection; only a small proportion of MDR-TB cases were associated with recent transmission. |
| Databáze: | OpenAIRE |
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