Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors

Autor:	Tsz Cheung Chong, Iris L. K. Wong, Kin-Fai Chan, Xuezhen Zhu, Jiahua Cui, Larry M.C. Chow, Man Chun Law, Tak Hang Chan, Xuesen Hu
Rok vydání:	2019
Předmět:	Abcg2 Flavonoid Triazole Bcrp abcg2 Antineoplastic Agents 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Mice Drug Discovery BCRP Inhibitors ATP Binding Cassette Transporter Subfamily G Member 2 Animals Humans Computer Simulation ATP Binding Cassette Transporter Subfamily B Member 1 030304 developmental biology chemistry.chemical_classification Flavonoids 0303 health sciences biology Chemistry 3T3 Cells Triazoles Highly selective Flavones Drug Resistance Multiple 0104 chemical sciences Neoplasm Proteins 010404 medicinal & biomolecular chemistry HEK293 Cells Biochemistry Drug Resistance Neoplasm Drug Design biology.protein Molecular Medicine Multidrug Resistance-Associated Proteins human activities Dimerization Copper
Zdroj:	Journal of medicinal chemistry. 62(18)
ISSN:	1520-4804
Popis:	The present work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective BCRP inhibitors. A homodimer, Ac22(Az8)2, with m-methoxyc...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42028e016a19b53895555a1f5cf8f143 https://pubmed.ncbi.nlm.nih.gov/31465686 Zobrazit plný text záznamu