Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: report from the second year of the SENTRY Antimicrobial Surveillance Program (1998)
| Autor: | Ana C. Gales, Ronald N. Jones, Kelley A. Gordon, Hélio S. Sader, Werner W. Wilke, Mondell L. Beach, Michael A. Pfaller, Gary V. Doern, the SENTRY Study Group Latin America |
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| Přispěvatelé: | Univ Iowa, Universidade Federal de São Paulo (UNIFESP) |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
Imipenem Klebsiella pneumoniae Cefepime Anti-Infective Agents Urinary Ceftazidime Microbial Sensitivity Tests Drug resistance beta-Lactams Meropenem beta-Lactamases Microbiology Anti-Infective Agents medicine Humans Pharmacology (medical) Pharmacology Molecular Epidemiology Bacteria biology business.industry biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial biology.organism_classification Drug Resistance Multiple Anti-Bacterial Agents Hospitalization Ciprofloxacin Latin America Infectious Diseases Urinary Tract Infections business Fluoroquinolones medicine.drug |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| Popis: | The potency and spectrum of various antimicrobial agents tested against 434 bacterial isolates causing urinary tract infection (UTI) in hospitalized patients in Latin America were evaluated. the genotypes of the extended-spectrum beta-lactamase-producing and selected multi-resistant isolates were also evaluated by molecular typing techniques. Escherichia coli (60.4%) was the most common aetiological agent causing UTI, followed by Klebsiella spp. (11.2%) and Pseudomonas aeruginosa (8.3%). in contrast, Enterococcus spp. isolates caused only 2.3% of UTIs. Fewer than 50% of E. coli isolates were susceptible to broad-spectrum penicillins. the resistance rates to ciprofloxacin and the new quinolones were also high among these isolates. the molecular characterization of ciprofloxacin-resistant E coli showed that most of them have a double mutation in the gyrA gene associated with a single mutation in the parC gene. the Klebsiella pneumoniae isolates studied demonstrated high resistance rates to beta-lactam drugs, including broad-spectrum cephalosporins. the carbapenems were the compounds with the highest susceptibility rate among these isolates (100.0% susceptible) followed by cefepime (91.7% susceptible). Meropenem, imipenem and cefepime were also the most active drugs against Enterobacter spp. Among P. aeruginosa isolates, meropenem (MIC50, 2 mg/L) was the most active compound, followed by imipenem (MIC50, 4 mg/L), cefepime (MIC50, 8 mg/L) end ceftazidime (MIC50, 16 mg/L). the results presented in this report confirm that bacterial resistance continues to be a great problem in Latin American medical institutions. Univ Iowa, Coll Med, Dept Pathol, Div Med Microbiol, Iowa City, IA 52242 USA Universidade Federal de São Paulo, Lab Especial Microbiol, Div Infect Dis, São Paulo, Brazil Universidade Federal de São Paulo, Lab Especial Microbiol, Div Infect Dis, São Paulo, Brazil Web of Science |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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