Aggregation-based fluorescence amplification strategy: 'turn-on' sensing of aminoglycosides using near-IR carbocyanine dyes and pre-micellar surfactants
| Autor: | Irina A. Doroshenko, Sergei S. Abramchuk, Sofia A. Zakharenkova, Anna S. Kriveleva, Tatyana A. Vidinchuk, Mikhail K. Beklemishev, Tatyana A. Podrugina, Aleksandra N. Lebedeva, Ekaterina A. Katkova, Anna V. Shik |
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| Rok vydání: | 2020 |
| Předmět: |
Nanoparticle
02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Fluorescence spectroscopy Analytical Chemistry chemistry.chemical_compound Surface-Active Agents Dynamic light scattering Bromide Sodium dodecyl sulfate Instrumentation Spectroscopy Micelles Chemistry Cationic polymerization Sodium Dodecyl Sulfate Carbocyanines 021001 nanoscience & nanotechnology Fluorescence Atomic and Molecular Physics and Optics 0104 chemical sciences Aminoglycosides Self-assembly 0210 nano-technology |
| Zdroj: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 247 |
| ISSN: | 1873-3557 |
| Popis: | This study is aimed at developing sensing schemes without obtaining selective receptors. A series of simple carbocyanine dyes was synthesized, whose emission was quenched in water with formation of nanoparticles in the range of 20-100 nm. Fluorescence in near-IR region is "turned on" in the presence of a drug cation of middle molecular weight (400-700 Da) and sodium dodecyl sulfate (SDS), as well as anionic drugs and a cationic surfactant (cetyltrimethylammonium bromide, CTAB). Aggregates (clusters) up to 100-200 nm in size were detected using dynamic light scattering (DLS) and Rayleigh light scattering (RLS) techniques in the systems: cationic analyte-SDS, carbocyanine dye-CTAB, and in all brightly fluorescent ternary systems dye-surfactant-analyte. Small ions (200 Da) incapable of multi-point binding do not form the aggregates or cause the emission enhancement. The "turn-on" signal is only observed at the surfactant submicellar concentrations insufficient to solubilize the dye nanoparticles. Based on these findings, we suggest a rapid and simple method for the detection of ≥4·10 |
| Databáze: | OpenAIRE |
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