Estimating Bordetella pertussis seroprevalence in adolescents and young adults in Mexico using the 2012 National Health and Nutrition Survey (ENSANUT)
| Autor: | Eduardo Ortega-Barria, Martin Romero-Martínez, Maria Yolanda Cervantes-Apolinar, María Olamendi-Portugal, Rodrigo DeAntonio, Gabriela Echániz-Aviles, Ricardo Cortes-Alcala, Celia Alpuche-Aranda, S. García-Cisneros, Miguel Angel Sánchez-Alemán |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bordetella pertussis Adolescent Whooping Cough Population Pertussis toxin Young Adult Seroepidemiologic Studies Environmental health Epidemiology Humans Medicine Seroprevalence Young adult education Mexico education.field_of_study General Veterinary General Immunology and Microbiology biology business.industry Transmission (medicine) Public Health Environmental and Occupational Health Infant Nutrition Surveys biology.organism_classification Vaccination Infectious Diseases Molecular Medicine business |
| Zdroj: | Vaccine. 39:5839-5844 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2021.08.063 |
| Popis: | Background Low vaccination rates and under-detection of pertussis infections in adolescents and young adults have an impact on the transmission of pertussis to infants. In this study, the proportion of adolescents and young adults with IgG antibodies against B. pertussis antigens, representing recent infection or vaccination, was estimated in a population-based probabilistic survey in Mexico. Methods Sera and data from 1,581 subjects, including 1,102 adolescents and 479 young adults (10–19 and 20–25 years old, respectively) randomly selected from Mexico’s 2012 National Health and Nutrition Survey, were analyzed. IgG antibodies against pertussis toxin (PT) were measured with the CDC/FDA ELISA. A subset of 234 samples was additionally tested with Bp-IgG PT ELISA kit (EUROIMMUN AG, Lubeck, Germany). Threshold values from corresponding test kits were used to identify recent infection or vaccination. Results Overall anti-PT IgG seroprevalence was 3.9% (95% CI: 2.3–6.3); 3.1% (95% CI: 1.9–5.0) in adolescents, and 4.9% (95% CI: 2.2–11) in young adults. Seroprevalence did not significantly vary by sex, socioeconomic status, region or rural/urban location. Compared to the CDC/FDA ELISA, the EUROIMMUN test showed a 76% sensitivity and 88% specificity. The weighted estimates represent a considerable burden of recent infection in adolescents and young adults; however, most adolescents and adults were seronegative and, therefore, susceptible to pertussis infection. Conclusion Since booster vaccination to B. pertussis after toddlerhood is not recommended in the Mexican national policy, anti-PT IgG seropositivity may be reasonably attributed to recent infection. Assessing pertussis seroprevalence requires careful consideration of the diagnostic test threshold interpretation and epidemiological model used. |
| Databáze: | OpenAIRE |
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