Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation
| Autor: | Sarah E. Webb, Jeffrey J. Kelu, Andrew L. Miller |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Keratinocytes
0301 basic medicine Cell type T-Lymphocytes Cellular differentiation Embryonic Development Osteoclasts Endosomes General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Calcium Signaling Zebrafish Calcium signaling Neurons Regulation of gene expression Nicotinic acid adenine dinucleotide phosphate biology Embryogenesis Endothelial Cells Gene Expression Regulation Developmental Cell Differentiation Epithelial Cells Zebrafish Proteins biology.organism_classification Cell biology 030104 developmental biology PERSPECTIVES chemistry Calcium Female Calcium Channels Signal transduction 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Cold Spring Harb Perspect Biol |
| ISSN: | 1943-0264 |
| DOI: | 10.1101/cshperspect.a035170 |
| Popis: | Since the identification of nicotinic acid adenine dinucleotide phosphate (NAADP) and its putative target, the two-pore channel (TPC), the NAADP/TPC/Ca(2+) signaling pathway has been reported to play a role in a diverse range of functions in a variety of different cell types. TPCs have also been associated with a number of diseases, which arise when their activity is perturbed. In addition, TPCs have been shown to play key roles in various embryological processes and during the differentiation of a variety of cell types. Here, we review the role of NAADP/TPC/Ca(2+) signaling during early embryonic development and cellular differentiation. We pay particular attention to the role of TPC2 in the development and maturation of early neuromuscular activity in zebrafish, and during the differentiation of isolated osteoclasts, endothelial cells, and keratinocytes. Our aim is to emphasize the conserved features of TPC-mediated Ca(2+) signaling in a number of selected examples. |
| Databáze: | OpenAIRE |
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