Probiotics versus antibiotic decontamination of the digestive tract: infection and mortality

Autor: Annelies Verbon, Jan-Harm Zwaveling, Alfons G. H. Kessels, Guy J. Oudhuis, Tom P J Dormans, Dennis C J J Bergmans, Ellen E. Stobberingh, Martin H. Prins
Přispěvatelé: Internal Medicine, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: CAPHRI School for Public Health and Primary Care, Epidemiologie, MUMC+: KIO Kemta (9), Med Microbiol, Infect Dis & Infect Prev, Intensive Care
Rok vydání: 2010
Předmět:
Male
ACUTE-PANCREATITIS
Survival
Antibiotics
Critical Care and Intensive Care Medicine
DOUBLE-BLIND
Lactobacillus
Infection control
Decontamination
Aged
80 and over
Cross Infection
SELECTIVE DECONTAMINATION
NOSOCOMIAL INFECTIONS
biology
Human decontamination
Middle Aged
RANDOMIZED CONTROLLED-TRIAL
Anti-Bacterial Agents
Intensive Care Units
Female
CRITICALLY-ILL PATIENTS
Adult
musculoskeletal diseases
medicine.medical_specialty
Adolescent
medicine.drug_class
ENTERAL NUTRITION
INTENSIVE-CARE
GUT BARRIER FUNCTION
Young Adult
Intensive care
Internal medicine
Anesthesiology
Preoperative Care
medicine
Humans
Intensive care medicine
Aged
Retrospective Studies
business.industry
Probiotics
biology.organism_classification
Gastrointestinal Tract
Critical care
Parenteral nutrition
TRAUMA PATIENTS
business
Lactobacillus plantarum
Zdroj: Intensive Care Medicine, 37(1), 110-117. Springer-Verlag
Intensive Care Medicine, 37(1), 110-117. Springer, Cham
ISSN: 1432-1238
0342-4642
DOI: 10.1007/s00134-010-2002-6
Popis: Selective decontamination of the digestive tract (SDD) has been shown to decrease the infection rate and mortality in intensive care units (ICUs); Lactobacillus plantarum 299/299v plus fibre (LAB) has been used for infection prevention and does not harbour the potential disadvantages of antibiotics. The objective was to assess whether LAB is not inferior to SDD in infection prevention.Two hundred fifty-four consecutive ICU patients with expected mechanical ventilation a parts per thousand yen48 h and/or expected ICU stay a parts per thousand yen72 h were assigned to receive SDD: four times daily an oral paste (polymyxin E, gentamicin, amphotericin B), enteral solution (same antibiotics), intravenous cefotaxime (first 4 days) or LAB: two times daily L. plantarum 299/299v with rose-hip.The primary endpoint was infection rate. A difference The trial could not demonstrate the non-inferiority of LAB compared with SDD in infection prevention. Results suggest no increased ICU mortality risk in the LAB group.
Databáze: OpenAIRE
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