Benton Judgment of Line Orientation (JoLO) Test: A Brief and Useful Measure for Assessing Visuospatial Abilities in Manifest, but not Premanifest, Huntington’s Disease
Autor: | Jody Corey-Bloom, Andrew Herndon, Shea Gluhm, Ameera Haque, Sungmee Park, Paul E. Gilbert |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Judgment of Line Orientation Dementia rating scale Neuropsychological Tests Audiology Developmental psychology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Huntington's disease Disease severity medicine Humans Case-control study Cognition Middle Aged medicine.disease Visuospatial ability Test (assessment) Huntington Disease 030104 developmental biology Case-Control Studies Space Perception Female Neurology (clinical) Psychology 030217 neurology & neurosurgery |
Zdroj: | Journal of Huntington's Disease. 5:91-96 |
ISSN: | 1879-6400 1879-6397 |
Popis: | BACKGROUND Visuospatial deficits have been described in Huntington's disease (HD); however, the extent of these deficits remains unclear. The Benton Judgment of Line Orientation (JoLO) Test, commonly used to assess visuospatial ability, requires minimal motor involvement. It has demonstrated sensitivity to visuospatial deficits in Parkinson's disease; however, few studies have examined performance on this test in HD. OBJECTIVE The objective of the current study was to assess visuospatial ability in premanifest and manifest HD using the JoLO. METHODS A global cognitive measure, the Mattis Dementia Rating Scale (DRS), was used to stratify manifest HD patients as mild (DRS ≥129) vs. moderate-severe (DRS ≤128). Fifty mild, 42 moderate-severe, and 30 premanifest HD subjects, as well as 35 matched controls, were administered the JoLO. HD Burden of Pathology (BOP) scores were used as a measure of disease severity. RESULTS Results revealed that the total manifest HD sample (p < 0.001), in addition to the mild (p = 0.028), and moderate-severe (p < 0.001), but not premanifest, HD subjects scored significantly lower on the JoLO compared to normal controls. CONCLUSIONS Our results suggest that the JoLO is useful for detecting visuospatial deficits across various stages of manifest HD. However, any visuospatial impairment that might be present during the premanifest stage of HD was not detected using the JoLO in the present sample. |
Databáze: | OpenAIRE |
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