Prevalence of sickle cell disorders and malaria infection in children aged 1–12 years in the Volta Region, Ghana: a community-based study
| Autor: | Mavis Oppong, Bernard Tornyigah, Margaret Kweku, Michael F. Ofori, Belinda Aculley, Helena Lamptey, Eric Kyei-Baafour, Ebenezer Addo Ofori |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Plasmodium falciparum 030231 tropical medicine Anemia Sickle Cell Parasitemia Ghana 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Prevalence medicine Humans 030212 general & internal medicine Malaria Falciparum Child Children Sickle-cell disorders biology business.industry Research Public health Sickle cell disorders Infant Anthropometry biology.organism_classification medicine.disease Malaria Infectious Diseases Parasitology Volta region Child Preschool Tropical medicine Female business |
| Zdroj: | Malaria Journal |
| ISSN: | 1475-2875 |
| Popis: | Background Alterations in the structure of haemoglobin (Hb) are usually brought about by point mutations affecting one or, in some cases, two codons encoding amino acids of the globin chains. One in three Ghanaians are said to have sickle cell disorders, whereas malaria continues to be one of the leading causes of mortality among children. This study determined the prevalence of sickle cell disorders and malaria infection among children aged 1–12 years in the Volta Region. Methods This was a community-based cross-sectional survey that involved 938 children aged 1–12 years selected from three districts, one each from the 3 geographical zones of the Volta Region using a multistage sampling method. Demographic information was collected using a standard questionnaire and anthropometric indices were measured. Isoelectric focusing (IEF) electrophoresis was used to determine the Hb genotypes and sub-microscopic parasites were determined by PCR. Results The prevalence of sickling screening positive was 16.0% with an overall prevalence of sickle cell disorders being 2.0%. Among the individual genotypes making up the sickle cell disorders, genotype HbSF was the highest (0.9% as compared to 0.2%; HbSS, 0.6%; HbSC and 0.3%; HbSCF). Microscopic Plasmodium falciparum parasitaemia was detected among 5.5% of the children and 14.2% sub-microscopic prevalence by PCR. Children with sickle cell disorders were more likely to have sub-microscopic parasitaemia (AOR = 5.51 95%CI (2.15, 14.10), p p = 0.042), compared to those with normal genotypes. There was no significant difference observed between sickle cell disorders and growth and development of the children screened. Conclusions Sickle cell disorders were significantly associated with sub-microscopic parasitaemia as well as anaemia in this study. Establishment of sickle cell clinics in the district and regional hospitals will help in the management of children with the disorder and also generate a national database on sickle cell disorders. National neonatal screening policies must also be put in place to help in early detection and management of these disorders. |
| Databáze: | OpenAIRE |
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