Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice
| Autor: | Yong Sze Ong, Yin Sim Tor, Latifah Saiful Yazan, Jhi Biau Foo, Razana Mohd Ali, Nur Elena Zaaba |
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| Rok vydání: | 2015 |
| Předmět: |
lcsh:Arctic medicine. Tropical medicine
biology Toxicity business.industry lcsh:RC955-962 Cancer Dillenia suffruticosa 4T1 Tumor-bearing mice Pharmacology biology.organism_classification medicine.disease Biochemistry Genetics and Molecular Biology (miscellaneous) Acute toxicity BALB/c Metastasis Toxicology Breast cancer lcsh:Biology (General) medicine Adverse effect business lcsh:QH301-705.5 |
| Zdroj: | Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 12, Pp 1018-1026 (2015) |
| ISSN: | 2221-1691 |
| DOI: | 10.1016/j.apjtb.2015.09.008 |
| Popis: | Objective To determine the anti-breast cancer activities and the safety oral consumption of Dillenia suffruticosa root aqueous extract (DRAE) in BALB/c mice. Methods In the anti-breast cancer study, female BALB/c mice were divided into five groups ( n = 12), which were (1) positive control (with breast cancer, untreated), (2) negative control (without breast cancer, untreated) and other three groups of mice with breast cancer treated with 1 000, 500 and 250 mg/kg of DRAE, respectively, by oral gavage for 28 days. All mice except from the negative control group were injected into the mammary fat pad with 4T1 cells (1 × 10 5 4T1 cells/0.1 mL of phosphate buffer solution). DRAE was administered orally on Day 11 after the tumor has developed. Results The tumor volume of the 1 000 mg/kg of DRAE group reduced significantly compared to the positive control while treatment with 500 mg/kg of DRAE had significantly inhibited metastasis to the heart. In the acute toxicity study, treatment with up to 5 000 mg/kg of DRAE was not toxic to the animals, indicating its safety when a large amount of this plant extract was ingested. Based on the sub-acute toxicity study, treatment of the highest dose of DRAE (1 000 mg/kg) had mild liver toxicity indicated by mild focal hemorrhage. Conclusions DRAE possesses anti-breast cancer properties but at the same time it shows mild toxicity to the liver. The non observable adverse effect dose for DRAE is 500 mg/kg. |
| Databáze: | OpenAIRE |
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