pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

Autor:	Sana Asada, Masaaki Ohba, Shogo Ide, Koki Kawahara, Tomomi Koshiyama, Kazuma Yasuhara, Yuki Inoue
Rok vydání:	2021
Předmět:	Metal ions in aqueous solution Lipid Bilayers Inorganic chemistry Ph dependent Ion Channels Permeability Catalysis Ion Metal Structure-Activity Relationship 2 2'-Dipyridyl Coordination Complexes Amphotericin B Materials Chemistry medicine Ion permeability Chemistry Metals and Alloys General Chemistry Hydrogen-Ion Concentration bacterial infections and mycoses humanities Surfaces Coatings and Films Electronic Optical and Magnetic Materials Membrane visual_art Ceramics and Composites visual_art.visual_art_medium Membrane channel Calcium Copper medicine.drug
Zdroj:	Chemical Communications. 57:2895-2898
ISSN:	1364-548X 1359-7345
DOI:	10.1039/d0cc08368b
Popis:	Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ ion permeability with a selective response to Cu2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f78001b49d0bd104ec45aa4f73d390 https://doi.org/10.1039/d0cc08368b Zobrazit plný text záznamu