Overweight and obesity during adolescence increases the risk of renal cell carcinoma
| Autor: | Pernilla Sundqvist, Scott Montgomery, Anna Fält, Anna Landberg, Katja Fall |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty renal cell carcinoma obesity Adolescent Adolescent Health Overweight urologic and male genital diseases Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Carcinoma Renal Cell Aged Sweden business.industry Proportional hazards model Hazard ratio Middle Aged medicine.disease Obesity female genital diseases and pregnancy complications Kidney Neoplasms Cancer registry Oncology 030220 oncology & carcinogenesis Cohort adolescence medicine.symptom business Weight gain Body mass index Cancer Epidemiology |
| Zdroj: | International Journal of Cancer |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | While overweight among adults has been linked with renal cell carcinoma (RCC) risk, little is known about the potential influence of overweight and obesity during adolescence. To ascertain if adolescent body mass index is associated with subsequent risk of RCC, we identified a cohort of 238,788 Swedish men who underwent mandatory military conscription assessment between 1969 and 1976 at a mean age of 18.5 years. At the time of conscription assessment, physical and psychological tests were performed including measurements of height and weight. Participants were followed through linkage to the Swedish Cancer Registry to identify incident diagnoses of RCC. The association between body mass index (BMI, kg/m2) at conscription assessment and subsequent RCC was evaluated using multivariable Cox regression. During a follow‐up of up to 37 years, 266 men were diagnosed with RCC. We observed a trend for higher RCC risk with increasing BMI during adolescence, where one‐unit increase in BMI conferred a 6% increased risk of RCC (95% CI 1.01–1.10). compared to normal weight men (BMI 18.5‐ What's new? While overweight among adults has been linked with renal cell carcinoma risk, little is known about the potential influence of overweight and obesity during adolescence. This large prospective cohort study over more than 35 years suggests that the link between overweight/obesity—alone and in combination with low physical working capacity—and renal cell carcinoma is already established in late adolescence. Prevention of unhealthy weight gain during childhood and adolescence may thus be a target in efforts to decrease the burden of renal cell carcinoma in the adult population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text