Immune restoration does not invariably occur following long term HIV-1 suppression during antiretroviral therapy
| Autor: | Herman G. Sprenger, P. T. A. Schellekens, Frank P. Kroon, David A. Hall, F. W. Wit, Jsg Montaner, Frank Miedema, Peter Reiss, Eugene Kroon, J. M. A. Lange, Dörte Hamann, R.H. Kauffmann, Marijke T. L. Roos, C. H. H. ten Napel, Peter P. Koopmans, H. M. Weigel, M. E. Van Der Ende, S.J. Otto, F. A. P. Claessen, Nadine Pakker |
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| Rok vydání: | 1999 |
| Předmět: |
Infections in patients with decreased host defence
education.field_of_study Nevirapine Combination therapy business.industry Immunology Population Infecties bij verminderde weerstand virus diseases CD28 Zidovudine Infectious Diseases Immune system Immunology and Allergy Medicine business education Didanosine CD8 medicine.drug |
| Zdroj: | Aids, 13, 203-212 Aids, 13, pp. 203-212 |
| ISSN: | 0269-9370 |
| Popis: | Background: Current antiretroviral treatment can induce significant and sustained virological and immunological responses in HIV-1-infected persons over at least the short- to mid-term. Objectives: In this study, long-term immune reconstitution was investigated during highly active antiretroviral therapy. Methods: Patients enrolled in the INCAS study in The Netherlands were treated for 102 weeks (range 52-144 weeks) with nevirapine (NVP) + zidovudine (ZDV) (n = 9), didanosine (ddl) + ZDV (n 10), or NVP + ddl + ZDV (n = 10). Memory and naive CD4+ and CD8+ T cells were measured using CD45RA and CD27 monoclonal antibodies (mAb), T-cell function was assayed by CD3 + CD28 mAb stimulation, and plasma HIV-1 RNA load was measured by ultra-direct assay (cut-off |
| Databáze: | OpenAIRE |
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