A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer
| Autor: | Mikdat BOZER, Fatma AŞIK, Muradiye ACAR, Hacer HALTAŞ, Sibel YENİDÜNYA, Metin CANBAL, Vehap TOPÇU, Muhammet Ramazan YİĞİTOĞLU, Mehmet GÜNDÜZ, Esra GÜNDÜZ, Satoshi HİROHATA, Kadir DEMİRCAN |
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| Rok vydání: | 2013 |
| Předmět: |
Climate pattern
endocrine system Antarctic ice sheet Key words: Breast cancer lymphatic metastasis ADAMTS9 gene promoter region dinucleotide repeats General Medicine Vegetation Structural basin Seasonality medicine.disease Habitat medicine Physical geography skin and connective tissue diseases Palaeogeography Paleogene Geology |
| Zdroj: | Volume: 43, Issue: 5 671-677 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | This paper concentrates on the Early Oligocene palaeoclimate of the southern part of Eastern and Central Europe and gives a detailed climatological analysis, combined with leaf-morphological studies and modelling of the palaeoatmospheric CO2 level using stomatal and d13C data. Climate data are calculated using the Coexistence Approach for Kiscellian floras of the Palaeogene Basin (Hungary and Slovenia) and coeval assemblages from Central and Southeastern Europe. Potential microclimatic or habitat variations are considered using morphometric analysis of fossil leaves from Hungarian, Slovenian and Italian floras. Reconstruction of CO2 is performed by applying a recently introduced mechanistic model. Results of climate analysis indicate distinct latitudinal and longitudinal climate patterns for various variables which agree well with reconstructed palaeogeography and vegetation. Calculated climate variables in general suggest a warm and frost-free climate with low seasonal variation of temperature. A difference in temperature parameters is recorded between localities from Central and Southeastern Europe, manifested mainly in the mean temperature of the coldest month. Results of morphometric analysis suggest microclimatic or habitat difference among studied floras. Extending the scarce information available on atmospheric CO2 levels during the Oligocene, we provide data for a well-defined time-interval. Reconstructed atmospheric CO2 levels agree well with threshold values for Antarctic ice sheet growth suggested by recent modelling studies. The successful application of the mechanistic model for the reconstruction of atmospheric CO2 levels raises new possibitities for future climate inference from macro-flora studies. |
| Databáze: | OpenAIRE |
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