Dietary vitamin A intake below the recommended daily intake during pregnancy and the risk of congenital diaphragmatic hernia in the offspring
| Autor: | Leonardus W. J. E. Beurskens, Régine P.M. Steegers-Theunissen, Mark F. Wildhagen, Jan Lindemans, Dick Tibboel, Jeanne H.M. de Vries, Maarten F. C. M. Knapen, Lieske H. Schrijver |
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| Přispěvatelé: | Pediatric Surgery, Obstetrics & Gynecology, Public Health, Clinical Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Vitamin
Adult Embryology medicine.medical_specialty Offspring Physiology Gestational Age Reference Daily Intake Risk Assessment Nutrition Policy chemistry.chemical_compound Pregnancy Internal medicine Prenatal Diagnosis medicine Humans Vitamin A Netherlands VLAG Hernia Diaphragmatic Global Nutrition Congenital malformations Wereldvoeding Dose-Response Relationship Drug business.industry Vitamin A Deficiency Retinol General Medicine Odds ratio Body-mass-index medicine.disease Carotenoids Diet Endocrinology chemistry Case-Control Studies Pediatrics Perinatology and Child Health Dietary Supplements Female Underweight medicine.symptom business Hernias Diaphragmatic Congenital Body mass index Developmental Biology Maternal Age |
| Zdroj: | Birth Defects Res. Part A-Clin. Mol. Teratol. 97 (2013) 1 Birth Defects Res. Part A-Clin. Mol. Teratol., 97(1), 60-66 Birth Defects Research Part A-Clinical and Molecular Teratology, 97(1), 60-66. Wiley-Liss Inc. |
| ISSN: | 1542-9768 1542-0752 |
| Popis: | BACKGROUND Vitamin A has been related to the etiology of congenital diaphragmatic hernia (CDH). We performed a case-control study to investigate whether maternal dietary vitamin A intake is related to CDH in the offspring. METHODS Thirty-one pregnancies diagnosed with CDH and 46 control pregnancies were included during the study. After CDH diagnosis and inclusion of controls by risk set sampling, maternal vitamin A intake was investigated with a food frequency questionnaire. Serum retinol and retinol-binding protein were determined. Univariable and multivariable logistic regression models were used to calculate risk estimates with adjustment for potential confounders. RESULTS We found no significant differences in the overall nutrient and vitamin A intake between case and control mothers. After stratification in body mass index (BMI) categories, case mothers with normal weight showed a lower energy adjusted vitamin A intake (685 vs. 843 μg retinol activity equivalents [RAEs] / day; p = 0.04) and a slightly lower serum retinol (1.58 vs. 1.67 μmol/L; p = 0.08) than control mothers. Vitamin A intake |
| Databáze: | OpenAIRE |
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