Calcium Homeostasis During Oral Glucose Load in Healthy Women
| Autor: | M. Acca, D'Erasmo E, D. Pisani, N. Raejntroph, A. Ragno, Elio Giancarlo Vecci |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Parathyroid hormone chemistry.chemical_element Calcium Biochemistry Endocrinology Internal medicine Hyperinsulinemia Homeostasis Humans Medicine Calcium metabolism Glucose tolerance test medicine.diagnostic_test business.industry Insulin Biochemistry (medical) General Medicine Parathyroid chief cell Glucose Tolerance Test Middle Aged medicine.disease Urinary calcium calcium glucose healthy women insulin parathyroid hormone Kinetics chemistry Parathyroid Hormone Creatinine Female business |
| Zdroj: | Hormone and Metabolic Research. 31:271-273 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-978731 |
| Popis: | It has been demonstrated that in healthy subjects during oral glucose tolerance test, serum calcium declines, while urinary calcium excretion increases, even if there is not a general agreement in this regard. The study was carried out in order to evaluate the effects of glucose oral load on calcium homeostasis in eight healthy adult women, also considering ionized calcium, plasma insulin and parathyroid hormone changes. The results showed a decline of total and ionized serum calcium (p < 0.05 and p < 0.01, respectively; maximum of the decrease at time 120'), in parallel with the increase of urinary calcium/ creatinine ratio (p < 0.05). Serum glucose and insulin increase (p < 0.0001 and p < 0.0005 respectively; maximum value at time 60'), while the parathyroid hormone level decreases (maximum decline at time 120', p < 0.01). No changes were observed in fasting control subjects for all parameters considered. The changes of these parameters with time suggest that the effects of glucose oral load on calcium metabolism in healthy adult women may be the consequence of parathyroid hormone suppression induced by acute hyperglycemia/hyperinsulinemia. The results confirm in vivo the PTH behaviour in vitro, on cultured bovine parathyroid cells, with high glucose concentration. |
| Databáze: | OpenAIRE |
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