Myelitis Due to Varicella-Zoster Virus in Two Patients with AIDS: Successful Treatment with Acyclovir
| Autor: | Flore Rozenberg, C. Petitdidier, Patrick Davous, Marc Pulik, Pierre Lebon, Françcois Lionnet, Philippe Genet |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Microbiology (medical) Herpesvirus 3 Human medicine.medical_specialty viruses Acyclovir Myelitis medicine.disease_cause Antiviral Agents Asymptomatic Herpesviridae Virus medicine Humans Aciclovir Sida AIDS-Related Opportunistic Infections integumentary system biology business.industry Varicella zoster virus virus diseases Herpesviridae Infections biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Dermatology Infectious Diseases DNA Viral Immunology Female Viral disease medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Only a few cases of varicella-zoster virus (VZV) myelitis have been described, and nearly all have been diagnosed post-mortem. There have been no reports in the literature of successful treatment of VZV myelitis with antiviral medications. We report on two patients with AIDS who had acute severe myelitis accompanied by herpes zoster. The presence of VZV DNA in cerebrospinal fluid (CSF) was documented by the polymerase chain reaction (PCR) technique. Early treatment with acyclovir was followed by a slow but complete recovery after a phase of initial aggravation. After a follow-up of > 1 year, the two patients remained asymptomatic. We conclude that (1) VZV should be considered a curable cause of myelitis in patients with AIDS, (2) PCR assay of CSF will assist in early diagnosis, and (3) early treatment with acyclovir should aid in recovery. |
| Databáze: | OpenAIRE |
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