Basement membranes in obstructive pulmonary diseases

Autor: Shehab I. Saad, Bart G. J. Dekkers, Janette K. Burgess, Leah J. van Spelde
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Pathology
medicine.medical_specialty
Histology
ASM
airway smooth muscle
QH301-705.5
Biophysics
Pulmonary disease
Review Article
Disease
Biochemistry
Extracellular matrix
ADAM9
a metalloproteinase domain 9
Genetics
medicine
Col IV
collagen IV
Biology (General)
skin and connective tissue diseases
Molecular Biology
Asthma
Basement membrane
Collagen IV
TIMP
tissue inhibitors of metalloproteinase
business.industry
Chronic obstructive pulmonary disease
Cell Biology
Airway remodeling
respiratory system
medicine.disease
respiratory tract diseases
ECM
extracellular matrix
Th2
T helper 2
MMP
matrix metalloproteinase
medicine.anatomical_structure
Membrane
BM
basement membrane
COPD
chronic obstructive pulmonary disease
VSM
vascular smooth muscle
sense organs
Laminin
Obstructive Pulmonary Diseases
business
Airway
LN
laminin
Airway inflammation
Zdroj: Matrix Biology Plus, Vol 12, Iss, Pp 100092-(2021)
Matrix Biology Plus
ISSN: 2590-0285
Popis: Highlights • Basement membrane composition is changed in the airways of patients with obstructive airway diseases. • Basement membrane changes are linked to disease characteristics in patients. • Mechanisms behind the altered BM composition remain to be elucidated. • Laminin and collagen IV affect key pathological processes in obstructive airway diseases.
Increased and changed deposition of extracellular matrix proteins is a key feature of airway wall remodeling in obstructive pulmonary diseases, including asthma and chronic obstructive pulmonary disease. Studies have highlighted that the deposition of various basement membrane proteins in the lung tissue is altered and that these changes reflect tissue compartment specificity. Inflammatory responses in both diseases may result in the deregulation of production and degradation of these proteins. In addition to their role in tissue development and integrity, emerging evidence indicates that basement membrane proteins also actively modulate cellular processes in obstructive airway diseases, contributing to disease development, progression and maintenance. In this review, we summarize the changes in basement membrane composition in airway remodeling in obstructive airway diseases and explore their potential application as innovative targets for treatment development.
Databáze: OpenAIRE
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