| Popis: |
Both carbazole and thiosemicarbazide scaffold showed various potential biological activities in medicinal chemistry. In this research work, we synthesized a series of carbazole bearing thiosemicarbazide derivatives (17-28) and evaluated thierin vitrocytotoxicity (IC50) profile on the U87 MG cell line using MTT assay. All target compounds were well characterized by NMR and HRMS mass spectroscopy. In series, six compounds (17, 20, 21, 22, 23, 28) found betterin vitrocytotoxicity (IC50) values were 26.50 µM, 34.0 µM, 39 µM, 80 µM, 62 µM, 50 µM respectively compare to standard drug Temozolomide (IC50 = 100 µM). The SAR study of all final compounds (17-28) were also analyzed on the basis of different substituents on 6th position of carbazole scaffold bearing thiosemicarbazide derivatives against U87 MG cell line. All of the above studies showed that carbazole bearing thiosemicarbazide derivatives (17-28) showed anticipated anticancer activity against U87 MG glioma cell line. |
