Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial

Autor: Cristóbal Pavón, Ainara Gómez-Gastiasoro, Nagore Iriarte-Yoller, Naroa Ibarretxe-Bilbao, Mikel Tous-Espelosin, Javier Peña, Agurne Sampedro, Natalia Ojeda, Pedro M. Sanchez
Rok vydání: 2021
Předmět:
Zdroj: Addi. Archivo Digital para la Docencia y la Investigación
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NPJ Schizophrenia
npj Schizophrenia, Vol 7, Iss 1, Pp 1-11 (2021)
ISSN: 2334-265X
DOI: 10.1038/s41537-021-00181-0
Popis: [EN] This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity. This work was supported by the Carlos III Health Institute of the Spanish Ministry of Economy and Competitiveness (PI16/01022); the Department of Education and Science of the Basque Government (Team A) (IT946-16); the Fundacion Tatiana Perez de Guzman el Bueno (to AS); and the University of the Basque Country (UPV/EHU) (PIF 19/40 to MTE). The funding agencies had no role in the design, data collection, and analysis, decision to publish, or preparation of the study. The authors thank all the participants and clinical teams who were involved in this study as well as the English language editing service. Our special thanks to Amaia Ortiz de Zarate, Edorta Elizagarate, and Isabel Hervella for all the support in the recruitment and management of patients.
Databáze: OpenAIRE
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